Application of Cp2TiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to [a]-Annelated Indoles
Hina P A Khan1, Tushar Kanti Chakraborty1
1Department of Organic Chemistry, Indian Institute of Science, Bengaluru 560012, India.
Abstract:
An efficient and novel route for assembling pyrrolo/piperido[1,2-a]indoles is portrayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step. Capitalizing on the operational simplicity of the method involving just two steps and use of an efficient C-C bond-forming reaction, this radical-based protocol enables the modular assembly of an important class of N-fused indole derivatives with versatile functional and structural diversity.
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