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Fibroblast growth factor 21 (FGF21) in children and adolescents with chronic kidney disease

Z Gamrot1, P Adamczyk, E Świętochowska

  • 1Unit of Paediatric Hematology and Oncology, Chorzow City Hospital, Chorzow, Poland; Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland. szczep57@poczta.onet.pl or dializy_dzieciece_zabrze@poczta.onet.p.

Physiological Research
|May 30, 2020
PubMed

Insights

Fibroblast growth factor 21 (FGF21) shows higher serum levels in pediatric chronic kidney disease (CKD) patients. Urine FGF21 levels correlate with kidney function, but more research is needed to confirm its role as a biomarker in children.

Area of Science:

  • Endocrinology
  • Nephrology
  • Metabolic research

Background:

  • Fibroblast growth factor 21 (FGF21) regulates glucose and lipid metabolism.
  • FGF21 is implicated in kidney function and considered a marker for early kidney decline.
  • Limited data exists on FGF21 in pediatric chronic kidney disease (CKD).

Purpose of the Study:

  • To investigate the relationship between plasma and urine FGF21 levels and kidney function in pediatric CKD patients.
  • To explore FGF21 as a potential biomarker for kidney function decline in children.

Main Methods:

  • Studied 42 pediatric patients with CKD.
  • Measured serum and urine FGF21 concentrations using enzyme immunoassay.
  • Assessed anthropometrical parameters, blood pressure, and routine biochemical tests, including eGFR and albuminuria.

Main Results:

  • Children with CKD exhibited significantly higher serum FGF21 concentrations.
  • Serum FGF21 levels did not correlate with gender, proteinuria, eGFR, or renal replacement therapy.
  • Urine FGF21 concentration showed a negative correlation with albuminuria and a positive correlation with eGFR.

Conclusions:

  • While serum FGF21 is elevated in pediatric CKD, its utility as a predictive biomarker is not yet established.
  • Urine FGF21 levels correlate with kidney function parameters like eGFR and albuminuria.
  • Further investigation is required to understand the role of FGF21, including local kidney production and extrarenal influences, in pediatric kidney disease.

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