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Late-onset Hypogonadism: Bone health
1Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Andrology
|May 30, 2020
Summary
Men with late-onset hypogonadism (LOH) face risks of osteoporosis and fractures. Testosterone replacement therapy (TRT) may improve bone mineral density (BMD) and prevent bone loss in these individuals.
Area of Science:
- Endocrinology
- Bone Metabolism
- Men's Health
Background:
- Bone health issues are frequently overlooked in men.
- Bone loss is common in aging men and those with hypogonadism.
- Late-onset hypogonadism (LOH) increases the risk of osteoporosis and fractures.
Purpose of the Study:
- To review current research on bone health in men with LOH.
- To discuss clinical implications of LOH on bone health.
- To update on data regarding osteoporosis in aging men with hypogonadism.
Main Methods:
- Literature review of PubMed publications.
- Focused search on bone health in older men with hypogonadism.
- Inclusion of relevant derived articles.
Main Results:
- Late-onset hypogonadism (LOH) is linked to reduced bone mineral density (BMD).
- Testosterone (T) and estradiol (E2) levels are crucial for preventing bone loss.
- Testosterone replacement therapy (TRT) generally increases BMD and prevents bone loss in hypogonadal men.
Conclusions:
- Men with LOH require evaluation for osteoporosis and bone-specific therapies.
- Testosterone replacement therapy (TRT) can positively impact bone health in men with LOH.
- TRT initiation should follow male hypogonadism guidelines.
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