The risk of preterm birth in vanishing twin: A multicenter prospective cohort study
Ji Su Seong1, You Jung Han2, Min Hyoung Kim3
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Objective:
To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT).
Study Design:
This is a secondary analysis of a multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery.
Results:
A total of 4,746 women were included in the final analysis, and. the frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception.
Conclusion:
Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.
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