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Updated: Dec 20, 2025
Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis
Published on: June 10, 2022
[Ileocolonic intussusception in an adolescent patient with cystic fibrosis]
Adriana E Bustamante1,2, Claudia Y Rodríguez-Garza1,3, Lourdes Mascareñas-Martínez1,4
1Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González".
Insights
Intestinal intussusception, a rare cause of acute abdomen in older children, occurred in a cystic fibrosis patient. Surgery revealed a cecal tumor, highlighting potential organic causes in this population.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Medical Genetics
Background:
- Intestinal intussusception is a common cause of bowel obstruction in infants but rare in older children.
- Cystic fibrosis (CF) can present with gastrointestinal complications, including distal intestinal obstruction syndrome (DIOS).
Observation:
- A 16-year-old male with cystic fibrosis presented with acute abdominal pain and a palpable mass, suggestive of distal intestinal occlusion syndrome.
- Imaging revealed ileocolonic intussusception with signs of intestinal ischemia, necrosis, and pneumatosis.
Findings:
- Surgical exploration identified a cecal tumor as the underlying cause of intussusception.
- This case highlights a rare presentation of acute abdomen in a young cystic fibrosis patient.
Implications:
- Intussusception in older children, particularly those with cystic fibrosis, warrants thorough investigation for underlying organic pathologies.
- Early diagnosis and surgical intervention are crucial for managing complications like ischemia and necrosis.
Abstract:
Intestinal intussusception occurs when a proximal segment of the intestine telescopes into the lumen of an adjacent distal segment, causing intestinal obstruction. It is a common cause of acute abdomen in the first two years of life, but rare in older children. A 16-year-old male with a diagnosis of cystic fibrosis presented with symptoms compatible with distal intestinal occlusion syndrome. He came at the cystic fibrosis clinic with a 5-day evolution of abdominal pain and a palpable mass in the right hypochondrium. Abdominal ultrasound and abdominal contrasted tomography were performed demonstrating ileocolonic invagination with signs of intestinal ischemia, necrosis and pneumatosis of the intestinal wall. He underwent surgery with resection of the terminal ileum and right hemicolon, and a tumor in the caecum was found. This is a rare cause of acute abdomen in young patients with cystic fibrosis and may be associated with an underlying organic cause.
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