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Updated: Dec 20, 2025

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Black soybean improves the vascular function through an increase in nitric oxide and a decrease in oxidative stress

Yoko Yamashita1, Liuqing Wang1, Asuka Nakamura1

  • 1Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan.

Archives of Biochemistry and Biophysics
|May 30, 2020
PubMed
Summary

Black soybean consumption improved vascular function and reduced oxidative stress in healthy women. This dietary intervention increased nitric oxide and polyphenol levels, contributing to better cardiovascular health.

Keywords:
Black soybean polyphenolNitric oxideOxidative stressPolyphenolVascular function

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Area of Science:

  • Nutrition Science
  • Cardiovascular Health
  • Oxidative Stress Research

Background:

  • Vascular dysfunction and oxidative stress are key risk factors for cardiovascular diseases (CVD).
  • Dietary polyphenols, found abundantly in black soybeans, show potential in mitigating CVD risk.
  • Previous animal studies suggest black soybeans have preventive effects against CVD.

Purpose of the Study:

  • To investigate the impact of black soybean consumption on vascular function in healthy women.
  • To assess changes in oxidative stress markers and polyphenol concentrations following black soybean intake.
  • To explore the relationship between polyphenol levels and improvements in vascular health.

Main Methods:

  • An 8-week dietary intervention study involving healthy women consuming black soybean.
  • Measurement of vascular age, vascular stiffness, and urinary nitric oxide metabolites (NO2, NO3).
  • Analysis of oxidative stress biomarkers (8-hydroxy-2'-deoxyguanosine, hexanoyl-lysine, myeloperoxidase) and plasma/urine polyphenol concentrations.

Main Results:

  • A significant portion of participants (33/44) showed lowered vascular age.
  • Improvements observed in vascular stiffness and increased urinary nitric oxide metabolites.
  • Reduced levels of key oxidative stress markers and increased plasma/urine concentrations of 12 black soybean polyphenols.

Conclusions:

  • Black soybean consumption positively impacts vascular function in healthy women.
  • The observed benefits are linked to increased nitric oxide availability and reduced oxidative stress.
  • Elevated polyphenol concentrations resulting from black soybean intake play a role in these protective effects.