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Updated: Dec 20, 2025
11:15
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
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Extracellular vesicle cross-talk in the liposarcoma microenvironment
Lucia Casadei1, Raphael E Pollock1
1The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Cancer Letters
|May 30, 2020
Summary
Dedifferentiated liposarcoma (DDLPS) is a dangerous soft tissue cancer. This review explores how extracellular vesicles (EVs) mediate interactions within the tumor microenvironment (TME), impacting DDLPS progression and recurrence.
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Dedifferentiated liposarcoma (DDLPS) is the most common soft tissue sarcoma subtype.
- DDLPS has a high rate of recurrence and poor prognosis, with a 10-year survival rate of only 10%.
- The molecular mechanisms driving DDLPS and its interaction with the tumor microenvironment (TME) are poorly understood.
Purpose of the Study:
- To review the role of the tumor microenvironment (TME) in DDLPS progression and recurrence.
- To focus on the function of extracellular vesicles (EVs) in mediating intercellular communication within the DDLPS TME.
- To highlight the potential of understanding EV-mediated TME interactions for developing novel therapeutic strategies.
Main Methods:
- Literature review focusing on DDLPS, TME, and extracellular vesicles.
- Analysis of existing research on EV biogenesis, cargo, and uptake.
- Synthesis of information regarding EV-mediated signaling pathways in the context of DDLPS.
Main Results:
- Extracellular vesicles (EVs) are key mediators of intercellular communication within the TME.
- DDLPS-derived EVs can transfer bioactive molecules to recipient cells, influencing tumor progression and recurrence.
- Understanding these EV-TME interactions is crucial for deciphering DDLPS biology.
Conclusions:
- The TME plays a significant role in DDLPS progression and recurrence.
- EVs are critical players in modulating the DDLPS TME.
- Further research into EV-TME interactions may unveil new therapeutic targets for DDLPS.
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