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Calligraphed Selective Plasmonic Arrays on Paper Platforms for Complementary Dual Optical "ON/OFF Switch" Sensing
Laurentiu Susu1,2, Andreea Campu1,2, Simion Astilean1,2
1Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Treboniu Laurean No. 42, Cluj-Napoca 400271, Romania.
Nanomaterials (Basel, Switzerland)
|May 31, 2020
Summary
This study introduces a low-cost plasmonic calligraphy method for multiplexed biosensing. The technique uses a ballpoint pen to draw nanoparticle lines on paper, enabling simultaneous detection of multiple analytes with high specificity.
Area of Science:
- Nanotechnology
- Biosensing
- Plasmonics
Background:
- Multiplexed biosensor development faces challenges in creating low-cost, simple devices for detecting multiple analytes simultaneously.
- Existing platforms often lack the versatility required for simultaneous chemical detection using a single engineered device.
Purpose of the Study:
- To develop a simple, low-cost multiplexed plasmonic array platform for chemical detection.
- To demonstrate the fabrication of a versatile plasmonic paper using plasmonic calligraphy.
- To enable simultaneous detection of multiple analytes on the same plasmonic line.
Main Methods:
- Plasmonic calligraphy using a ballpoint pen with gold bipyramids (AuBPs) and gold nanorods (AuNRs) as colloidal inks on Whatman paper.
- Immobilization of AuBPs and AuNRs onto paper fibers, confirmed by Scanning Electron Microscopy (SEM).
- Coating plasmonic lines with poly(styrene sulfonate) to create charge-selective regions for enhanced specificity.
- Dual optical sensing using Surface-enhanced Raman Scattering (SERS) and metal-enhanced fluorescence (MEF) for analyte detection.
Main Results:
- Successful fabrication of a multiplexed plasmonic array on paper via plasmonic calligraphy.
- Demonstrated charge-selective regions enabling specific analyte binding.
- Achieved dual optical "ON/OFF Switch" sensing for anionic (Rose-Bengal) and cationic (Rhodamine 6G) analytes on the same plasmonic line.
- Verified nanoparticle immobilization and array formation using SEM.
Conclusions:
- Plasmonic calligraphy offers a versatile and low-cost approach for fabricating multiplexed biosensing platforms.
- The developed charge-selective plasmonic array enables simultaneous detection of different analytes.
- This platform has potential for biomarker detection in complex biological mixtures.
