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Comparison between Diffusion-Weighted Sequences with Selective and Non-Selective Fat Suppression in the Evaluation of
Ilze Apine1,2, Reinis Pitura2, Ivanda Franckevica1,3
1Children Clinical University Hospital of Riga, LV 1004 Riga, Latvia.
Abstract:
Background: We compared the efficiency of two MRI diffusion weighted imaging (DWI) techniques: DWI with SPIR (DWISPIR) and DWI with STIR (DWISTIR), to estimate their eligibility for quantitative assessment of Crohn's disease activity in children and adults. Methods: In inflamed terminal ileum segments (n = 32 in adults, n = 46 in children), Magnetic Resonance Index of Activity (MaRIA) was calculated, ADC values of both DWI techniques were measured, and the corresponding Clermont scores calculated. ADC values of both DWI techniques were compared between both and within each patient group, assessing their mutual correlation. Correlations between MaRIA and the corresponding ADC values, and Clermont scores based on both DWI techniques were estimated. Results: No correlation between ADC of DWISPIR and DWISTIR was observed (rho = 0.27, p = 0.13 in adults, rho = 0.20, p = 0.17 in children). The correlation between MaRIA and Clermont scores was strong in both techniques-in SPIR, rho = 0.93; p < 0.0005 in adults, rho = 0.98, p < 0.0005 in children, and, in STIR, rho = 0.89; p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children. The correlation between ADC and MaRIA was moderate negative for DWISTIR (rho = 0.93, p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children), but, in DWISTIR, no correlation between ADC and MaRIA score was observed in adults (rho = -0.001, p = 0.99), whereas children presented low negative correlation (rho = -0.374, p = 0.01). Conclusions: DWISTIR is not suitable for quantitative assessment of Crohn's disease activity both in children and adult patients.
Insights
Diffusion Weighted Imaging with STIR (DWISTIR) is unsuitable for quantifying Crohn's disease activity in children and adults. DWI with SPIR (DWISPIR) shows potential for quantitative assessment, correlating well with disease activity scores.
Area of Science:
- Radiology and Medical Imaging
- Gastroenterology
- Pediatric Gastroenterology
Background:
- Comparing Diffusion Weighted Imaging with SPIR (DWISPIR) and DWI with STIR (DWISTIR) for Crohn's disease activity assessment.
- Evaluating the eligibility of these MRI techniques for quantitative analysis in pediatric and adult patients.
Purpose of the Study:
- To determine the efficacy of DWISPIR and DWISTIR in quantitatively assessing Crohn's disease activity.
- To compare the correlation between MRI-derived scores and established clinical activity indices.
Main Methods:
- Inclusion of inflamed terminal ileum segments from 32 adults and 46 children.
- Calculation of Magnetic Resonance Index of Activity (MaRIA) and Clermont scores.
- Measurement of ADC values for both DWISPIR and DWISTIR, followed by correlation analyses.
Main Results:
- No significant correlation was found between ADC values from DWISPIR and DWISTIR in either adults or children.
- Strong correlations were observed between MaRIA and Clermont scores for both DWI techniques across all age groups.
- DWISTIR showed no correlation with MaRIA in adults and a low negative correlation in children; DWISPIR demonstrated a moderate negative correlation.
Conclusions:
- Diffusion Weighted Imaging with STIR (DWISTIR) is not recommended for the quantitative assessment of Crohn's disease activity in pediatric and adult populations.
- Diffusion Weighted Imaging with SPIR (DWISPIR) demonstrates suitability for quantitative Crohn's disease activity assessment, showing robust correlations with established disease indices.
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