Related Experiment Video
Updated: Dec 20, 2025
In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
Published on: June 15, 2018
Cognitive Deficits in Myopathies.
Eleni Peristeri1, Athina-Maria Aloizou1, Paraskevi Keramida1
1Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, 41110 Larissa, Greece.
This review examines cognitive deficits in myopathies, finding they often accompany muscle disease, particularly in hereditary forms like Duchenne muscular dystrophy and myotonic dystrophies.
Area of Science:
- Neurology
- Genetics
- Muscle Biology
Background:
- Myopathies are diverse skeletal muscle disorders affecting structure and function.
- Cognitive impairments are increasingly recognized in various myopathy subtypes.
- Hereditary myopathies, such as Duchenne muscular dystrophy (DMD) and myotonic dystrophies (MDs), are frequently associated with neurological involvement.
Purpose of the Study:
- To provide a comprehensive overview of cognitive deficits in myopathies.
- To explore the relationship between myopathy classification and associated cognitive impairments.
- To synthesize findings from recent literature on this topic.
Main Methods:
- Systematic literature search across PubMed, Scopus, and Google Scholar.
- Focus on studies reporting cognitive deficits alongside clinical observations and brain imaging findings.
- Prioritization of recent bibliographical sources.
Main Results:
- Cognitive deficits are frequently observed in patients with myopathies.
- Brain imaging often reveals lesions correlating with cognitive impairments.
- Hereditary myopathies, particularly DMD and MDs, show a notable prevalence of cognitive deficits.
Conclusions:
- Cognitive deficits are a significant, often overlooked, feature of myopathies.
- Understanding these deficits is crucial for comprehensive patient care.
- Further research is needed to elucidate the mechanisms underlying cognitive impairment in myopathies.
More Related Videos
08:16Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
12:18The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy
Published on: December 26, 2014
Related Concept Videos
01:28Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
01:15Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
01:20Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
01:26Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
01:26Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
01:26Cross-bridge Cycle