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Updated: Dec 20, 2025
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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Natural Nitrogenous Sesquiterpenoids and Their Bioactivity: A Review
De-Li Chen1,2, Bo-Wen Wang3, Zhao-Cui Sun1
1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.
Molecules (Basel, Switzerland)
|May 31, 2020
Summary
Nitrogen-containing natural sesquiterpenes are rare but possess valuable bioactivity. This review details 391 compounds isolated from 2010-2020, aiding future drug discovery.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Organic Chemistry
Background:
- Nitrogenous sesquiterpenoids are rare natural products.
- Their bioactivity and structural diversity remain largely unexplored.
- A comprehensive review is needed to consolidate existing knowledge.
Purpose of the Study:
- To review the isolation, identification, and bioactivity of nitrogenous sesquiterpenoids.
- To cover advancements in the field from 2010 to February 2020.
- To provide a foundation for discovering novel therapeutic agents.
Main Methods:
- Literature search for nitrogenous sesquiterpenoids.
- Analysis of isolation and identification techniques.
- Compilation of reported bioactivity data.
Main Results:
- Cataloged 391 nitrogen-containing sesquiterpenes.
- Included compounds from terrestrial plants, marine organisms, and microorganisms.
- Summarized diverse structural features and reported bioactivities.
Conclusions:
- Nitrogenous sesquiterpenoids represent a promising area for drug discovery.
- This review highlights their potential medicinal value.
- Further research into these compounds is warranted.
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