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Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo
Gitte Holmen Olofsson1, Agnete Witness Praest Jensen1, Manja Idorn2
1Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), University Hospital Herlev, 2730 Herlev, Denmark.
International Journal of Molecular Sciences
|May 31, 2020
Summary
Combining immunotherapy with exercise shows promise for cancer treatment. Exercise may enhance the immune system
Area of Science:
- Oncology
- Immunology
- Exercise Science
Background:
- Cancer immunotherapy (immuno-oncology) leverages the immune system to fight cancer, with some late-stage patients achieving cures.
- Despite advances, many patients do not benefit from current cancer treatments.
- Exercise is recognized for improving quality of life and managing chemotherapy side effects in cancer patients.
Purpose of the Study:
- To explore the potential synergistic effects of combining exercise with cancer immunotherapy.
- To investigate how exercise influences the immune system in the context of cancer treatment.
Main Methods:
- Review of preclinical cancer models and human studies on exercise and cancer.
- Analysis of exercise-induced immunological changes, including immune cell mobilization and tumor microenvironment alterations.
Main Results:
- Animal studies indicate exercise has therapeutic effects in preclinical cancer models, mediated by the immune system.
- In humans, physical activity is linked to reduced cancer risk and potential clinical benefits for cancer patients.
- Exercise promotes immune cell redistribution and alters the tumor microenvironment immunologically.
Conclusions:
- Exercise may enhance the efficacy of cancer immunotherapy.
- Combining exercise with immunotherapy presents a promising strategy for improving cancer treatment outcomes.
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