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Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case

Michael G Argenziano1,2, Samuel L Bruce1,2, Cody L Slater1,2

  • 1Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

BMJ (Clinical Research Ed.)
|May 31, 2020
PubMed

Insights

This study characterized 1000 coronavirus disease 2019 (COVID-19) patients in NYC, revealing significant morbidity and mortality. COVID-19 patients faced high rates of acute kidney injury, dialysis, and prolonged intubations.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Epidemiology

Background:

  • Coronavirus disease 2019 (COVID-19) emerged as a global pandemic.
  • Understanding the clinical characteristics and outcomes of affected patients is crucial for effective management.

Purpose of the Study:

  • To characterize patients with COVID-19 at a major New York City medical center.
  • To describe the clinical course of COVID-19 patients across emergency, inpatient, and intensive care settings.

Main Methods:

  • Retrospective review of medical records for 1000 consecutive patients with confirmed SARS-CoV-2.
  • Manual abstraction of data including demographics, symptoms, comorbidities, hospital course, and outcomes.

Main Results:

  • The study included 1000 patients, with 236 admitted to intensive care units (ICUs).
  • Common symptoms included cough, fever, and dyspnea. ICU patients were older, predominantly male, and experienced prolonged stays.
  • High rates of acute kidney injury (78.0%) and need for dialysis (35.2%) were observed in ICU patients. Time to intubation showed a bimodal distribution.

Conclusions:

  • Hospitalized COVID-19 patients experienced substantial morbidity and mortality.
  • Key complications included acute kidney injury and need for dialysis.
  • The bimodal distribution of time to intubation suggests complex disease progression patterns.
Abstract

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