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Long-term follow-up of a randomized, double-blind, phase III, multi-centre study to evaluate the safety and efficacy of field-directed photodynamic therapy (PDT) of mild to moderate actinic keratosis using BF-200 ALA versus placebo and the BF-RhodoLED® lamp.

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[Actinic keratoses : Current guideline and practical recommendations].

D Nashan1, S Hüning2, M V Heppt3

  • 1Hautklinik, Klinikum Dortmund gGmbH, Beurhausstr. 40, 44137, Dortmund, Deutschland. Dorothee.Nashan@klinikumdo.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 31, 2020
PubMed
Summary

This overview addresses new questions on actinic keratosis and squamous cell carcinoma treatments, prompted by recent research. It clarifies therapy options and highlights areas needing further development for skin cancer management.

Keywords:
BK5103DiagnosisPrecision medicineS3 guidelineTherapy

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • The 2019 S3 guideline on actinic keratosis (AK) and squamous cell carcinoma (SCC) has faced subsequent scrutiny.
  • New publications raise questions about data comparability and evaluation heterogeneity due to varied parameters and treatment considerations.

Purpose of the Study:

  • To provide a concise overview of current developments and research concerning AK and SCC.
  • To address criticisms and identify necessary advancements in the field.

Main Methods:

  • Review of recent publications, reviews, and meta-analyses.
  • Analysis of epidemiological data, pathogenesis, prevention, clinical presentation, and therapeutic options for AK and SCC.
  • Inclusion of basic data, side effects, and features of therapeutic options for practical implementation.

Main Results:

  • Therapeutic options for AK and SCC are categorized into local destructive procedures and topical applications.
  • Recommendations are based on the current guideline, with evidence levels provided.
  • Identified are divergent measurement parameters and insufficient consideration of pre-treatments and combined treatments as sources of heterogeneity.

Conclusions:

  • The overview clarifies current developments and ongoing questions regarding actinic keratoses.
  • Highlights the need for further research and development to refine treatment protocols and improve comparability of study data in skin cancer management.