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Updated: Dec 20, 2025

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Clinical and Research Tools for the Study of Cardiovascular Effects of Cancer Therapy

Rafey A Feroze1, Jeff Leya2, Todd Herron2,3

  • 1Department of Medicine, University of Michigan, Ann Arbor, MI, USA.

Journal of Cardiovascular Translational Research
|May 31, 2020
PubMed

Insights

Cancer therapies can cause cardiotoxicity, impacting patient outcomes. New strategies are needed for early detection and risk assessment of this adverse effect.

Area of Science:

  • Oncology
  • Cardiology
  • Translational Medicine

Background:

  • Cancer therapeutics have advanced, improving outcomes but sometimes causing cardiotoxicity.
  • Cardiotoxicity affects a significant patient subset, often with poorly understood mechanisms.
  • Adverse cardiovascular outcomes complicate all stages of cancer treatment.

Purpose of the Study:

  • To provide an overview of current tools for evaluating cancer therapy-induced cardiotoxicity.
  • To highlight novel techniques for understanding cardiotoxicity's pathophysiologic mechanisms.
  • To address the need for improved risk-stratification and early identification of at-risk patients.

Main Methods:

  • Review of existing clinical and research tools for cardiotoxicity assessment.
  • Exploration of imaging modalities, blood-based biomarkers, and pluripotent stem cells.
  • Discussion of emerging techniques for mechanistic studies.

Main Results:

  • Current tools for cardiotoxicity evaluation include imaging and biomarkers.
  • Novel techniques are under development to elucidate underlying pathophysiologic mechanisms.
  • There is a critical need for advanced strategies in risk stratification and early detection.

Conclusions:

  • Effective management of cancer therapy requires addressing cardiotoxicity.
  • Novel tools are essential for understanding and mitigating cardiovascular risks associated with cancer treatments.
  • Further research into advanced diagnostic and mechanistic approaches is warranted.
Keywords:
BiomarkersCardiac CTCardiac MRICardio-oncologyCardiotoxicityNuclear imaging

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