Related Experiment Video

Updated: Dec 20, 2025

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

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The Adenovirus Death Protein - a small membrane protein controls cell lysis and disease

Fanny Georgi1, Urs F Greber1

  • 1Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

FEBS Letters
|May 31, 2020
PubMed

Insights

Human adenoviruses (HAdVs) cause infections, with the adenovirus death protein (ADP) crucial for viral spread. Understanding ADP

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Human adenoviruses (HAdVs) are common pathogens causing acute and persistent infections.
  • While typically mild, HAdV infections can be severe in immunocompromised individuals.
  • No current vaccines or therapies exist for HAdV diseases.

Purpose of the Study:

  • To review the mechanism by which the adenovirus death protein (ADP) induces host cell membrane rupture.
  • To highlight the significance of ADP-mediated membrane rupture in viral pathogenesis and therapeutic applications.

Main Methods:

  • Review of existing literature on adenovirus biology, focusing on the adenovirus death protein (ADP).
  • Analysis of ADP's structure, post-translational modifications, and cellular localization.
  • Discussion of the proposed mechanisms of ADP-induced membrane disruption.

Main Results:

  • ADP is a viral protein essential for progeny virus release through host cell lysis.
  • ADP localizes to the inner nuclear membrane after processing in the ER and Golgi.
  • ADP's membrane-spanning domain is implicated in inducing membrane rupture.

Conclusions:

  • ADP-mediated membrane rupture is critical for HAdV replication and spread.
  • Understanding ADP's function is vital for developing antiviral strategies and optimizing oncolytic virotherapy.
Keywords:
adenovirus death proteinapoptosiscancer therapycell deathcell lysishuman adenovirusmembrane ruptureoncolytic virusesvirus egressvirus transmission

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