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Prospective Multicenter Evaluation of an Advanced Extracellular Matrix for Wound Management
Rose Raizman1, Rosemary Hill, Kevin Woo
1Rose Raizman, RN-EC, NSWOC, MSc, is nurse practitioner and enterostomal therapist, Centenary Hospital, Toronto, Ontario, Canada. Rosemary Hill, RN, CWOCN, CETN(C), is Certified Wound Ostomy Continence Clinician, Lions Gate Hospital, North Vancouver, British Columbia; Kevin Woo, PhD, RN, NSWOC, WOCC(C), FAPWCA, is Associate Professor, Queens University, Kingston, Ontario. Acknowledgments: Aroa Biosurgery Limited (New Zealand) provided study products, editorial assistance, and travel grants for conference attendance to the authors. Endoform is currently available in the following countries: New Zealand, Canada, US, Germany, Thailand, Jordan, and Mexico. The authors have disclosed no other financial relationships related to this article. Submitted December 20, 2019; accepted in revised form February 19, 2020.
Objective:
To evaluate an advanced extracellular matrix made of ovine forestomach matrix (OFM) for healing a variety of wound types.
Methods:
Participants were enrolled from inpatient, outpatient, and home healthcare settings. The OFM was used to treat all wounds and applied to the wound bed every 3 to 7 days until closure.
Results:
Researchers enrolled 29 participants with 33 wounds. Average time to wound closure was 8.2 weeks, the percentage of wounds that reduced in size by 50% or more at 4 weeks was 64%, the average wound area reduction at 4 weeks was 66%, and 73% of wounds had closed at 12 weeks. No adverse effects were observed.
Conclusions:
This represents the first Canadian evaluation of OFM for the treatment of wounds, and the positive healing outcomes observed could support more widespread adoption of this matrix.
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