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Related Concept Videos

Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

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Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Related Experiment Video

Updated: Dec 20, 2025

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
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Goal-directed versus Standard Fluid Therapy to Decrease Ileus after Open Radical Cystectomy: A Prospective Randomized

Vittoria Arslan-Carlon1, Kay See Tan, Guido Dalbagni

  • 1From the Department of Anesthesiology and Critical Care Medicine, Anesthesiology Service (V.A.-C., A.C.P., M.F.) the Department of Epidemiology and Biostatistics (K.S.T.) the Department of Surgery, Urology Service (G.D., H.W.H., B.H.B., E.K.C., T.F.D., S.M.D.), Memorial Sloan Kettering Cancer Center, New York, New York the Departments of Urology (G.D., H.W.H., B.H.B., E.K.C., S.M.D.) Anesthesiology (A.C.P., M.F.), Weill Cornell Medical College, New York, New York.

Anesthesiology
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Summary
This summary is machine-generated.

Goal-directed fluid therapy did not reduce postoperative ileus rates in radical cystectomy patients. This study found no significant difference in ileus or complications between fluid management strategies.

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Area of Science:

  • Urology
  • Surgical Oncology
  • Critical Care Medicine

Background:

  • Postoperative ileus is a frequent complication following radical cystectomy, affecting up to 32% of patients.
  • Previous research on perioperative fluid administration's impact on ileus has been limited by inconsistent definitions and outcomes.
  • This study investigated whether individualized fluid management could mitigate postoperative ileus in this patient population.

Purpose of the Study:

  • To evaluate the efficacy of goal-directed fluid therapy (GDFT) compared to standard fluid therapy in reducing postoperative ileus after open radical cystectomy.
  • To assess the impact of GDFT on other postoperative complications within 30 days.

Main Methods:

  • A parallel-arm, double-blinded, single-center randomized trial was conducted.
  • Participants undergoing open radical cystectomy received either GDFT or standard fluid therapy.
  • GDFT involved optimizing stroke volume and minimizing stroke volume variation using advanced hemodynamic monitoring.

Main Results:

  • No significant difference in postoperative ileus incidence was observed between the GDFT arm (25%) and the standard fluid therapy arm (21%).
  • High-grade complications did not differ between groups, but acute kidney injury was more frequent in the GDFT group (56% vs. 40%).
  • The study included 283 patients between August 2014 and April 2018.

Conclusions:

  • Goal-directed fluid therapy does not appear to be an effective strategy for reducing the risk of postoperative ileus in patients undergoing open radical cystectomy.
  • The increased incidence of acute kidney injury in the GDFT group warrants further investigation.