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Related Experiment Video

Updated: Dec 20, 2025

Protocol for Dengue Infections in Mosquitoes A. aegypti and Infection Phenotype Determination
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Can dengue virus be sexually transmitted?

Martin P Grobusch1, Karin S van der Fluit2, Cornelis Stijnis2

  • 1Centre of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centres, Amsterdam Public Health, Amsterdam Infection & Immunity, Amsterdam, the Netherlands; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.

Travel Medicine and Infectious Disease
|May 31, 2020
PubMed
Summary

Dengue virus (DENV) shares similarities with Zika virus (ZIKV), raising questions about its sexual transmission. Evidence suggests DENV may transmit sexually, warranting further research into this potential human-to-human transmission route.

Keywords:
DENVDengueSemenSexual transmissionVaginal fluid

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Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Zika virus (ZIKV) is known to be sexually transmitted.
  • Dengue virus (DENV) and ZIKV are both Flaviviruses with similar molecular structures and transmission vectors.
  • Similarities suggest DENV might share pathophysiological pathways with ZIKV and other sexually transmitted viruses.

Purpose of the Study:

  • To evaluate the potential for sexual transmission of Dengue virus (DENV).
  • To review existing evidence, including anecdotal reports and recent case studies, regarding DENV presence in bodily fluids and potential sexual transmission.
  • To identify controversies and propose future research directions for understanding DENV sexual transmission.

Main Methods:

  • Literature review of anecdotal reports and scientific studies on DENV transmission.
  • Analysis of documented cases suggesting sexual transmission of DENV.
  • Comparative analysis of DENV and ZIKV characteristics.

Main Results:

  • DENV shares significant similarities with ZIKV, a known sexually transmitted virus.
  • Anecdotal evidence suggests prolonged presence of DENV in semen, urine, and vaginal secretions.
  • Two likely cases of DENV sexual transmission were reported in 2019.

Conclusions:

  • The possibility of Dengue virus (DENV) sexual transmission requires further investigation.
  • Existing evidence, though limited, supports the need for research into non-vectorial DENV transmission routes.
  • Further studies are crucial to confirm and understand the implications of DENV sexual transmission for public health.