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Published on: August 16, 2021
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Aortic Insufficiency During HeartMate 3 Left Ventricular Assist Device Support.
Teruhiko Imamura1, Nikhil Narang2, Gene Kim3
1(1)Department of Medicine, University of Chicago Medical Center, Chicago, Illinois; Second Department of Medicine, University of Toyama, Toyama, Japan.
Journal of Cardiac Failure
|May 31, 2020
Summary
Significant aortic insufficiency (AI) is common in HeartMate 3 left ventricular assist device (LVAD) patients. This condition increases the risk of death or heart failure readmission within one year.
Area of Science:
- Cardiology
- Medical Devices
- Heart Failure Management
Background:
- Aortic insufficiency (AI) is linked to poor outcomes in left ventricular assist device (LVAD) patients.
- The impact of AI on HeartMate 3 LVAD recipients is not well understood.
Purpose of the Study:
- To investigate the clinical significance of AI in patients receiving HeartMate 3 LVAD support.
- To determine the prevalence and impact of AI on adverse events in this population.
Main Methods:
- Retrospective analysis of 61 HeartMate 3 LVAD patients implanted between 2015-2019.
- Echocardiography at 3 months post-implantation to assess AI severity.
- Definition of significant AI as regurgitation fraction >= 30%.
Main Results:
- 20% of patients (12/61) had significant AI at 3 months post-implantation.
- Patients with significant AI experienced higher rates of death or heart failure readmission (70% vs 24%) within one year.
- Adjusted hazard ratio for adverse events in significant AI group was 2.76.
Conclusions:
- Significant AI is a prevalent complication in HeartMate 3 LVAD patients.
- AI is a clinically significant factor associated with adverse outcomes in this cohort.
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