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Cardiovascular ochronosis.

Nuvaira Ather1, William C Roberts2

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Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|May 31, 2020
PubMed
Summary
This summary is machine-generated.

This review details ochronosis, a condition causing black pigment in cardiovascular structures. It summarizes 66 case reports and highlights historical medical contributions to understanding ochronosis.

Keywords:
AlkaptonuriaAortic valveMinocyclineOchronosis

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Area of Science:

  • Cardiovascular Medicine
  • Pathology
  • Medical History

Background:

  • Ochronosis is a rare condition characterized by the deposition of ochronotic pigment.
  • This pigment can affect various tissues, including cardiovascular structures.
  • Understanding ochronosis is crucial for diagnosing and managing affected patients.

Observation:

  • This review synthesizes findings from 66 previously reported case reports.
  • Ochronotic pigment was identified in cardiovascular structures during necropsy or surgical excision.
  • Two illustrative cases involving excised aortic valves and aorta with black pigment are presented, likely secondary ochronosis.

Findings:

  • The presence of ochronotic pigment in cardiac valves, aorta, and arteries is documented.
  • Secondary ochronosis is suggested in the presented patient cases.
  • The review consolidates existing literature on cardiovascular manifestations of ochronosis.

Implications:

  • Highlights the importance of recognizing ochronotic pigment in cardiovascular tissues.
  • Provides a historical perspective on the study of ochronosis.
  • Informs clinicians about the potential cardiovascular involvement in ochronosis.