Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

278
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
278
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

778
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
778
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

220
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
220
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

287
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
287
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

239
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
239
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

560
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
560

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and rational of the the PRACTICAL-HERO trial: A randomized trial of higher and lower doses of heparin vs placebo for elective diagnostic coronary angiography.

American heart journal·2026
Same author

Defining Population at Risk and Assessment of Patients With Presumed Coronary Microvascular and Vasomotor Dysfunction.

The Canadian journal of cardiology·2026
Same author

A Standardized Invasive Protocol for the Investigation of Patients With Presumed Coronary Microvascular and Vasomotor Dysfunction.

The Canadian journal of cardiology·2026
Same author

Defining Metrics and the Framework for the Invasive Assessment of Patients With Presumed Coronary Microvascular and Vasomotor Dysfunction.

The Canadian journal of cardiology·2026
Same author

Design and rationale of the HD PCI trial: A cluster randomized crossover trial of higher vs. lower dose heparin for elective percutaneous coronary intervention.

American heart journal·2025
Same author

Hybrid management of iatrogenic right coronary artery occlusion during minimally invasive tricuspid valve repair.

JTCVS techniques·2025

Related Experiment Video

Updated: Dec 20, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.8K

Endothelial Dysfunction Is Not Associated With Spontaneous Coronary Artery Dissection.

Amir Solomonica1, Cassandra Wagner2, Shahar Lavi2

  • 1Rambam Medical Center, Department of Cardiology, Haifa, Israel.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|June 1, 2020
PubMed
Summary

Endothelial dysfunction (ED) is not associated with spontaneous coronary artery dissection (SCAD). This study found no evidence of ED in SCAD patients, suggesting it does not contribute to SCAD formation.

Keywords:
Blood vesselCoronary atherosclerosisDissectionVascular endothelium

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K
Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.9K

Related Experiment Videos

Last Updated: Dec 20, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.8K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K
Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.9K

Area of Science:

  • Cardiology
  • Vascular Biology
  • Pathophysiology

Background:

  • Spontaneous coronary artery dissection (SCAD) is a significant cause of acute coronary syndrome.
  • The underlying pathophysiology of SCAD remains incompletely understood.
  • This study investigated the potential link between endothelial dysfunction (ED) and SCAD.

Purpose of the Study:

  • To determine if endothelial dysfunction (ED) is associated with spontaneous coronary artery dissection (SCAD).
  • To compare endothelial function in patients with SCAD versus those with atherosclerotic coronary artery disease (AD).

Main Methods:

  • Prospective assessment of acute coronary syndrome patients diagnosed with SCAD.
  • Control group comprised patients with established atherosclerotic coronary artery disease (AD).
  • Endothelial function assessed using the EndoPAT 2000 device in a steady state.

Main Results:

  • Microvascular reactivity was significantly poorer in the atherosclerotic disease (AD) group compared to the SCAD group.
  • The median reactive hyperemia index (RHI) was lower in the AD group (1.76) than in the SCAD group (2.08).
  • Only one SCAD patient had an RHI below the 1.67 cut-off, compared to 50% of AD patients.

Conclusions:

  • Patients with SCAD did not exhibit endothelial dysfunction (ED).
  • Endothelial dysfunction is unlikely to be a contributing factor in the formation of SCAD.