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A mendelian randomization analysis: The causal association between serum uric acid and atrial fibrillation

Myunghee Hong1, Je-Wook Park1, Pil-Sung Yang2

  • 1Division of Cardiology, Department of Internal Medicine, Yonsei University Health System, Seoul, Korea.

European Journal of Clinical Investigation
|June 1, 2020
PubMed

Insights

High serum uric acid (UA) levels are linked to atrial fibrillation (AF) risk. Mendelian randomization analysis suggests a potential causal link, warranting further investigation into UA

Area of Science:

  • Cardiovascular Genetics
  • Metabolic Disorders
  • Epidemiology

Background:

  • Observational studies indicate a correlation between elevated serum uric acid (UA) and atrial fibrillation (AF).
  • The causal relationship between urate levels and AF risk remains unclear.
  • Mendelian randomization (MR) analysis is employed to investigate potential causal effects.

Purpose of the Study:

  • To determine the causal effect of serum uric acid (UA) on the risk of atrial fibrillation (AF).
  • To utilize genetic instrumental variables (IVs) for a robust causal inference.

Main Methods:

  • A Mendelian randomization (MR) analysis was conducted using a Korean GWAS dataset.
  • Data included 633 AF patients and 3533 controls.
  • Nine single nucleotide polymorphisms (SNPs) associated with UA levels were selected, and a weighted genetic risk score (wGRS) was calculated as an instrumental variable.

Main Results:

  • A significant conventional association (P = .001) was observed between serum UA and AF.
  • The SNP rs1165196 on SLC17A1 and the wGRS were significantly associated with increased UA levels.
  • MR analysis revealed a causal association between rs1165196 and AF risk (OR, 0.21; P = .017), but not with wGRS (OR, 1.07; P = .832).

Conclusions:

  • Serum uric acid levels are independently associated with an increased risk of atrial fibrillation (AF).
  • Specific genetic variants, like rs1165196, may mediate a causal link between UA and AF.
Abstract

Keywords:
Mendelian randomizationatrial fibrillationserum uric acid

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