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The role of FOXOs and autophagy in cancer and metastasis-Implications in therapeutic development

Mohd Farhan1, Marta Silva1, Shuai Li1

  • 1Faculty of Health Sciences, Centre of Reproduction, Development and Aging, Institute of Translational Medicine, University of Macau, Taipa, Macau SAR, China.

Medicinal Research Reviews
|June 1, 2020
PubMed

Insights

Forkhead box O (FOXO) proteins and autophagy are key regulators in cancer development and metastasis. This study explores their roles in cancer progression and potential therapeutic strategies.

Area of Science:

  • Cell Biology
  • Oncology
  • Molecular Biology

Background:

  • Autophagy is a critical cellular degradation process involved in cell survival and stress responses.
  • Autophagy dysfunction is implicated in cancer development and metastasis.
  • Forkhead box O (FOXO) transcription factors regulate genes crucial for metabolism and cancer signaling.

Purpose of the Study:

  • To summarize the role of FOXO proteins in cancer.
  • To elucidate the involvement of autophagy in cancer progression.
  • To analyze the combined roles of FOXOs and autophagy in cancer metastasis and disease management.

Main Methods:

  • Literature review of studies on FOXO transcription factors.
  • Analysis of research on autophagy mechanisms in cancer.
  • Synthesis of current evidence linking FOXOs, autophagy, and cancer.

Main Results:

  • FOXO proteins regulate genes involved in cellular metabolism and cancer-related signaling pathways.
  • FOXO proteins are increasingly recognized for their involvement in autophagy regulation.
  • The interplay between FOXOs and autophagy significantly impacts cancer growth and metastasis.

Conclusions:

  • FOXO proteins and autophagy are integral to cancer biology.
  • Understanding their relationship offers potential for novel cancer treatment strategies.
  • Targeting FOXOs and autophagy may provide new avenues for cancer disease management.
Keywords:
FOXO proteinsautophagycancermetastasis

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