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Updated: Dec 20, 2025
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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
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Auditory attention late effects in pediatric acute lymphoblastic leukemia
Alice Ann Holland1,2, Matthew A Clem1, Erin Lampson3
1Department of Psychiatry, University of Texas Southwestern Medical Center , Dallas, TX, USA.
Summary
Pediatric Acute Lymphoblastic Leukemia (ALL) survivors may experience lasting auditory attention deficits. These attention issues correlate with poorer academic performance, highlighting a need for targeted support.
Area of Science:
- Neuroscience
- Pediatric Oncology
- Cognitive Psychology
Background:
- Previous research indicates long-term cognitive effects in pediatric cancer survivors, particularly in visual attention.
- Acute Lymphoblastic Leukemia (ALL) treatment, even with chemotherapy alone, may impact neurodevelopmental outcomes.
- Auditory attention is a critical cognitive function for academic success and daily functioning.
Purpose of the Study:
- To investigate auditory attention functioning in pediatric ALL survivors treated with chemotherapy.
- To identify potential risk factors associated with auditory attention deficits in this population.
- To explore the relationship between auditory attention and academic outcomes in ALL survivors.
Main Methods:
- 107 pediatric ALL survivors completed the Conners Continuous Auditory Test of Attention (CATA).
- Parental reports on behavior, academic performance, and educational services were collected.
- Statistical analyses compared survivor performance to normative data and identified risk factors.
Main Results:
- While group means for auditory attention were average, 50% of survivors performed below one standard deviation from the norm on at least one CATA variable.
- Poorer sustained auditory attention was linked to negative academic outcomes.
- Higher methotrexate exposure and younger age at diagnosis were risk factors for inattentiveness.
Conclusions:
- Auditory attention is a vulnerable cognitive domain in pediatric ALL survivors.
- Auditory attention deficits are associated with academic difficulties in this population.
- Findings underscore the importance of monitoring and supporting cognitive function in ALL survivors post-treatment.
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