Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.0K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.0K
Seizures: Classification01:13

Seizures: Classification

1.2K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

1.1K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.1K
Overview of Synapses01:25

Overview of Synapses

4.4K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
4.4K
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

524
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
524
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

791
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
791

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Pediatric epilepsy surgery: Global survey of invasive explorations.

Epilepsia·2026
Same author

[<sup>18</sup>F]FDG PET/MRI in Pediatric Focal Epilepsies.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Beyond Broca and Wernicke: Epilepsy surgery in the language areas.

Epileptic disorders : international epilepsy journal with videotape·2026
Same author

Frontal Disconnection in a Case of Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy.

World neurosurgery·2026
Same author

Cortical and etiological determinants of stimulation-induced seizures in children undergoing stereo-EEG.

Epilepsia·2026

Related Experiment Video

Updated: Dec 20, 2025

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

21.1K

Epileptogenic Network Formation.

Luca de Palma1, Alessandro De Benedictis2, Nicola Specchio1

  • 1Rare and Complex Epilepsies, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, IRCCS, 4, Piazza Sant'Onofrio, Rome 00165, Italy.

Neurosurgery Clinics of North America
|June 2, 2020
PubMed
Summary
This summary is machine-generated.

Epilepsy involves altered brain network organization, including changes in cortical thickness and connectivity. Recognizing these network features is key for effective epilepsy surgery planning.

Keywords:
Epilepsy surgeryEpileptogenesisEpileptogenic networkPropagation network

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K
Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
07:58

Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents

Published on: September 15, 2011

9.6K

Related Experiment Videos

Last Updated: Dec 20, 2025

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

21.1K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K
Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
07:58

Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents

Published on: September 15, 2011

9.6K

Area of Science:

  • Neuroscience
  • Medical imaging
  • Epileptology

Background:

  • Epilepsy is defined by abnormal brain network organization.
  • Key factors include cortical thickness changes, pathological hubs, and white matter alterations.

Purpose of the Study:

  • To outline the network alterations characterizing epileptogenesis.
  • To highlight neurophysiologic biomarkers indicating transitions to seizures.
  • To emphasize the importance of these features for surgical planning.

Main Methods:

  • Analysis of network organization parameters in epilepsy.
  • Identification of alterations in cortical thickness.
  • Assessment of pathological hub development and distribution.
  • Evaluation of white matter integrity.
  • Characterization of neurophysiologic biomarkers.

Main Results:

  • Epileptogenesis involves altered cortical thickness, pathological hubs, and white matter changes.
  • Brain connectivity is reinforced in both epileptogenic and propagation zones.
  • Specific neurophysiologic biomarkers indicate a propensity to shift from interictal to ictal states.

Conclusions:

  • Understanding network alterations is crucial for epilepsy surgery.
  • Identifying specific biomarkers aids in surgical decision-making.
  • Network reorganization provides insights into epilepsy pathophysiology.