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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Updated: Dec 20, 2025

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Systemic Contact Dermatitis: A review.

Francesca Y Baruffi1, Kaushik P Venkatesh1, Kamaria N Nelson2

  • 1The George Washington School of Medicine and Health Sciences, Washington, DC, USA.

Dermatologic Clinics
|June 2, 2020
PubMed
Summary
This summary is machine-generated.

Systemic contact dermatitis (SCD) involves hypersensitivity reactions to allergens like plants, foods, metals, and medications. Diagnosis and treatment rely on patch testing and allergen avoidance diets.

Keywords:
Allergens/immunologyAvoidance dietsBaboon syndromeHypersensitivityPatch testSNASSystemic contact dermatitis

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Area of Science:

  • Immunology
  • Dermatology
  • Allergy

Background:

  • Systemic contact dermatitis (SCD) encompasses diverse syndromes with various triggers.
  • SCD is primarily understood as a Type IV hypersensitivity reaction, involving CD8+ T-cells upon reexposure.
  • Common allergens include plants, foods, metals, and medications.

Purpose of the Study:

  • To elucidate the immunological mechanisms underlying Systemic Contact Dermatitis.
  • To outline diagnostic approaches for SCD.
  • To detail therapeutic strategies for managing SCD.

Main Methods:

  • Review of existing literature on SCD pathogenesis and clinical presentation.
  • Analysis of diagnostic methodologies, focusing on epicutaneous patch testing.
  • Examination of treatment protocols, emphasizing allergen avoidance.

Main Results:

  • SCD is characterized by Type IV (T-cell mediated) and occasionally Type III hypersensitivity.
  • Allergens are broadly categorized into plants, foods, metals, and medications.
  • Epicutaneous patch testing demonstrates high diagnostic success rates.

Conclusions:

  • SCD is an immune-mediated condition triggered by systemic allergen reexposure.
  • Accurate diagnosis is achievable through patch testing.
  • Allergen avoidance diets are the cornerstone of SCD management.