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Related Experiment Video

Updated: Dec 20, 2025

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability

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Published on: April 22, 2016

Hydroxypropyl β-cyclodextrin improving multiple stresses tolerance of Lactococcus lactis subsp. lactis.

Lianming Cui¹, Songyang Lin¹, Juanjuan Yi¹

¹School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China.

Journal of Food Science

|June 2, 2020

Summary

Hydroxypropyl β-cyclodextrin (HP β-CD) enhances the survival and growth of Lactiplantibacillus lactis under various industrial stresses. This protective agent proved more effective than trehalose, safeguarding cell structure.

Keywords:

Lactococcus lactis subsp. Lactis hydroxypropyl β-cyclodextrin protective agent stress response

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Published on: June 16, 2022

Area of Science:

Food Microbiology
Industrial Biotechnology
Probiotic Research

Background:

Lactiplantibacillus lactis (L. lactis) is a key industrial starter for dairy and meat fermentation, valued as a probiotic.
Industrial processes expose L. lactis to stresses like heat, salt, cold, and hydrogen peroxide, impacting its growth and survival.
Trehalose is a known protectant, but its efficacy under multiple stresses requires comparison.

Purpose of the Study:

To investigate the protective effects of hydroxypropyl β-cyclodextrin (HP β-CD) on L. lactis against multiple industrial stresses.
To compare the protective efficacy of HP β-CD with trehalose.
To elucidate the potential protective mechanism of HP β-CD on L. lactis cell structure.

Main Methods:

L. lactis cultures were subjected to heat, NaCl, cold, and H2O2 stresses.
Cell growth was assessed using OD600 measurements and spot plating.
Cell structure integrity was examined via scanning electron microscopy and fluorescence spectroscopy.

Main Results:

HP β-CD significantly improved L. lactis growth and tolerance under all tested stress conditions.
HP β-CD demonstrated superior protective effects compared to trehalose.
Microscopic and spectroscopic analyses indicated that HP β-CD interacts with L. lactis cells, protecting their structure.

Conclusions:

HP β-CD is a potential protective agent for L. lactis in industrial food applications.
HP β-CD offers enhanced protection against multiple stresses compared to trehalose.
Further research is needed to fully understand the protective mechanisms of HP β-CD on L. lactis.