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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
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Plastics derived endocrine-disrupting compounds and their effects on early development
Sanjay Basak1, Mrinal K Das2, Asim K Duttaroy3
1Molecular Biology Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Birth Defects Research
|June 2, 2020
Summary
Exposure to plastic-derived endocrine-disrupting compounds (EDCs) during early development can negatively impact birth outcomes. These chemicals may program diseases and affect fetal development, highlighting the need for further research.
Area of Science:
- Environmental Health
- Developmental Biology
- Toxicology
Background:
- Bisphenols and phthalates are common endocrine-disrupting compounds (EDCs) found in plastics.
- Adverse health effects linked to EDCs include programming of diseases in multiple organs and immune system abnormalities.
- In utero exposure to EDCs can influence epigenetic transgenerational inheritance of adult-onset diseases.
Purpose of the Study:
- To review the current understanding of how plastic-derived EDCs impact early fetal development.
- To examine the effects of EDCs on fetal growth, gene expression, epigenetics, and angiogenic activities.
- To assess the potential consequences of EDC exposure on birth outcomes.
Main Methods:
- This is a review article, summarizing existing scientific literature.
- Data from studies investigating EDC exposure during preconception and gestation were analyzed.
- Focus on effects during critical developmental windows from spermatogenesis to fetal formation.
Main Results:
- Emerging data indicate that EDCs affect embryogenesis, placentation, and feto-placental development.
- Impaired early development due to EDC exposure is linked to developmental disorders.
- EDC exposure is an independent risk factor for adult chronic diseases.
Conclusions:
- Early developmental stages are highly susceptible to the programming effects of EDCs.
- Plastic-derived EDCs pose a significant risk to normal human birth and long-term health.
- Further investigation into EDC impacts on fetal development and birth outcomes is warranted.
Keywords:
11β-HSDsARsDNA methylationEDCERsIGFsTHRsbirth outcomebisphenol A (BPA)bisphenol F (BPF)bisphenol S (BPS)endocrine disruptorenvironmental estrogensepigeneticsexposurefetal programminggenome programmiRNAobesityphthalateplacentaplasticspolycystic ovary syndromepreeclampsiaMore Related Videos
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