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Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Related Experiment Video

Updated: Dec 20, 2025

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Published on: July 6, 2022

Aging Cartilage in Wild-Type Mice: An Observational Study.

Joulnar Akoum^1,2, Khadija Tahiri^1,2, Marie-Thérèse Corvol^1,2

¹INSERM UMRS 1124, Toxicité Environnementale, Cibles Thérapeutiques, Signalisation Cellulaire et Biomarqueurs (T3S), Campus Saint-Germain-des-Prés, Paris, France.

|June 2, 2020

Summary

Age-related knee osteoarthritis in mice shows worsening cartilage damage and slower walking speeds between 3 and 9 months. Serum biomarkers for cartilage breakdown (CTX-II) peaked earlier, preceding these changes.

Keywords:

age-related changes mouse model osteoarthritis

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Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

Area of Science:

Biomedical research
Osteoarthritis research
Animal models

Background:

Age-related changes in articular cartilage are a significant health concern.
Understanding the progression of osteoarthritis (OA) in animal models is crucial for developing effective treatments.
C57BL/6-JRj wild-type male mice are a common model for studying age-related diseases.

Purpose of the Study:

To characterize the spontaneous development of age-related knee joint articular cartilage changes.
To assess age-related alterations in walking speed.
To evaluate a serum biomarker for cartilage remodeling in C57BL/6-JRj wild-type male mice.

Main Methods:

Histological assessment of knee joint cartilage using the Osteoarthritis Research Society International (OARSI) score.
Measurement of walking speed using the Locotronic system.
Quantification of serum C-terminal telopeptide of type II collagen (CTX-II) by ELISA.

Main Results:

OARSI scores significantly increased between 1-3 months and 3-6 months of age.
Walking speed remained stable until 6 months, then significantly decreased between 6-9 months.
Serum CTX-II levels were highest at 1 month and decreased significantly by 3 months, remaining low thereafter.

Conclusions:

C57BL/6-JRj wild-type male mice exhibit progressive osteoarthritic changes with age.
Walking speed decline was delayed compared to the onset of cartilage degeneration.
Peak serum CTX-II levels preceded the most significant age-related changes in cartilage and locomotion.