Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

827
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
827
Vaccinations01:51

Vaccinations

50.8K
Overview
50.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic characterization of cellular responses to the fish allergen β-parvalbumin using ZenoSWATH-MS.

International journal of biological macromolecules·2026
Same author

Effect of Piperine Codelivery on the Oral Bioavailability of Cannabidiol: Insights from <i>In Vitro</i> Digestion and <i>In Vivo</i> Pharmacokinetics.

Journal of agricultural and food chemistry·2026
Same author

Editorial to "Hard-to-treat cancer: part II: drug delivery technologies and therapeutics strategies for pancreatic tumors, a hard-to-treat cancer".

Advanced drug delivery reviews·2026
Same author

Alveolar macrophages shape tuberculosis susceptibility by delaying protective immunity.

Mucosal immunology·2026
Same author

Sequential YAP1/FOSL1 silencing and epigenetic therapy to overcome stromal barriers in pancreatic cancer.

International journal of pharmaceutics·2025
Same author

Voltage-gated potassium channel isoform upregulation and functional alterations in multiple sclerosis peripheral blood mononuclear cells.

International immunopharmacology·2025

Related Experiment Video

Updated: Dec 20, 2025

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.9K

Polymeric nanostructure vaccines: applications and challenges.

Rosana Simón-Vázquez1,2, Mercedes Peleteiro2,3, África González-Fernández1,2

  • 1Immunology Group, Centro de Investigaciones Biomédicas, CINBIO, Universidade de Vigo, Campus Universitario Lagoas Marcosende , Vigo, Spain.

Expert Opinion on Drug Delivery
|June 2, 2020
PubMed
Summary
This summary is machine-generated.

Biocompatible polymers enable novel nanostructured vaccines for enhanced antigen delivery. Further research into immune responses and production methods is crucial for clinical translation of these promising polymer-based nanovaccines.

Keywords:
Adjuvantantibodyantigencellular immune responseclinical trialimmunogenicityimmunotherapynanovaccinepathogenprophylaxisprotection

More Related Videos

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

7.9K
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

2.9K

Related Experiment Videos

Last Updated: Dec 20, 2025

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.9K
Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

7.9K
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

2.9K

Area of Science:

  • Vaccine research and development
  • Polymer science in nanomedicine
  • Immunology and vaccinology

Background:

  • Biocompatible polymers from natural or synthetic sources are revolutionizing vaccine research.
  • These polymers facilitate the creation of nanostructured antigen carriers for efficient cellular uptake.
  • Adjuvants can be incorporated to enhance and modulate the immune response.

Purpose of the Study:

  • To review the historical and current use of polymers as antigen carriers in vaccine development.
  • To provide an overview of vaccine immunology.
  • To discuss advances, clinical trials, and challenges in polymer-based nanostructured vaccines.

Main Methods:

  • Review of literature on polymer-based nanovaccines.
  • Analysis of existing prototypes in clinical trials.
  • Discussion of immunological principles relevant to vaccination.

Main Results:

  • Polymeric nanostructures serve as effective antigen carriers, facilitating internalization by antigen-presenting cells.
  • Incorporation of adjuvants can significantly boost and fine-tune immune responses.
  • Several polymer-based nanovaccine prototypes are in clinical trials, demonstrating progress in the field.

Conclusions:

  • Polymeric nanostructured vaccines hold significant potential in modern vaccinology.
  • Market translation is hindered by limitations including the need for protection correlates and reproducible synthesis methods.
  • Advancements in understanding the immune system and disease pathophysiology are key to future progress.