[Chronic compensated syndrome of disseminated intravascular coagulation in Sjögren's disease]

Area of Science:

• Hematology
• Rheumatology
• Internal Medicine

Background:

• Sjogren's disease (SD) is an autoimmune disorder affecting exocrine glands.
• Hemostasis system disorders are observed in SD patients.
• The role of coagulation in SD pathogenesis requires further investigation.

Purpose of the Study:

• To investigate the hemostasis system in patients with Sjogren's disease.
• To determine the prevalence of chronic compensated disseminated intravascular coagulation (DIC) syndrome in SD.
• To evaluate the therapeutic effect of prednisolone and heparin on chronic DIC in SD.

Main Methods:

• Hemostasis system analysis in 40 SD patients and 30 healthy donors.
• Assessment of coagulative and anticoagulative system activation.
• Clinical evaluation of treatment response to prednisolone and heparin.

Main Results:

• SD patients exhibited activation of both coagulative and anticoagulative systems.
• Chronic compensated DIC syndrome was identified in approximately 50% of SD patients.
• Prednisolone combined with heparin demonstrated a positive therapeutic effect on chronic DIC.

Conclusions:

• Hemostasis system disorders, including chronic compensated DIC, are prevalent in Sjogren's disease.
• Microcirculatory and blood coagulation abnormalities may contribute to SD pathogenesis.
• Combination therapy with prednisolone and heparin shows promise for managing chronic DIC in SD.