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Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

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Published on: May 23, 2025

Isolated optic nerve sarcoidosis.

Sandip Suresh¹, Gregory S Kosmorsky², Michael S Lee^1,3

¹University of Minnesota Departments of Ophthalmology.

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG

|June 2, 2020

Summary

This summary is machine-generated.

Sarcoidosis can affect only the optic nerve, causing vision loss even without systemic signs. Optic nerve biopsy confirmed non-caseating granulomas, indicating this rare condition in optic neuropathy diagnoses.

Keywords:

optic nerve optic neuritis optic neuropathy sarcoidosis

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Area of Science:

Ophthalmology
Neurology
Pathology

Background:

Sarcoidosis is a multisystem inflammatory disease.
Optic nerve involvement in sarcoidosis typically occurs with systemic disease.

Observation:

Three patients presented with progressive visual loss.
Magnetic resonance imaging revealed optic nerve enhancement in all cases.
Systemic sarcoidosis or other infiltrative diseases were excluded.

Findings:

Optic nerve biopsies showed non-caseating granulomas.
Histopathology confirmed sarcoidosis confined to the optic nerve.

Implications:

Isolated optic nerve sarcoidosis is a rare diagnosis.
Consider optic nerve sarcoidosis in unexplained optic neuropathy, even without systemic manifestations.