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Postnatal Involution and Counter-Involution of the Thymus

Jennifer E Cowan1, Yousuke Takahama2, Avinash Bhandoola1

  • 1Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Frontiers in Immunology
|June 2, 2020
PubMed

Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.

Keywords:
Mycagingcyclin D1growthinvolutionthymus

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