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Related Experiment Video

Updated: Dec 20, 2025

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
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Neurotoxoplasmosis mimicking primary brain malignancy.

Jayesh Patel1, Melissa Swee1

  • 1University of Iowa Hospitals and Clinics, Iowa City, USA.

Idcases
|June 2, 2020
PubMed
Summary

Toxoplasma gondii infection can be life-threatening in transplant patients. A brain biopsy revealed cerebral toxoplasmosis mimicking a tumor in a long-term kidney and pancreas transplant recipient.

Area of Science:

  • Infectious Diseases
  • Transplantation Immunology
  • Neurology

Background:

  • Solid organ transplantation (SOT) recipients are immunocompromised, increasing susceptibility to opportunistic infections.
  • Toxoplasma gondii infection poses a significant risk, potentially leading to severe outcomes in this population.

Observation:

  • A case of cerebral toxoplasmosis presenting as a solitary intracranial space-occupying lesion is described.
  • The patient had undergone a combined kidney and pancreas transplant over twenty years prior.

Findings:

  • Initial brain imaging suggested a primary brain malignancy.
  • A brain biopsy was crucial for accurate diagnosis, identifying Toxoplasma gondii infection.

Implications:

Keywords:
ToxoplasmosisTransplant infection

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  • This case highlights the importance of considering opportunistic infections like toxoplasmosis in immunocompromised transplant patients, even years post-transplant.
  • Diagnostic challenges emphasize the need for thorough investigation, including biopsy, when imaging is ambiguous.