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Updated: Dec 20, 2025
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Validation of Whole Blood Rapid Diagnosis Test for Hepatitis B
Jose D Debes1,2, Gertine van Oord2, Andre Boonstra2
1Department of Medicine, University of Minnesota, Minneapolis, MN, US.
Abstract:
We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all genotypes other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensitivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.
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