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An infant who suffered seizures many times after pentavalent vaccination: A case report

Meryem Erat Nergiz1, Hande Yetisgin1, Alperen Aydin1

  • 1Department of Pediatrics, Ankara Yildirim Beyazit University, Yenimahalle Training and Research Hospital, Ankara, Turkey.

Northern Clinics of Istanbul
|June 2, 2020
PubMed

Insights

Serious adverse effects from vaccines are rare. A 2-month-old infant experienced seizures after receiving the acellular pertussis vaccine component of pentavalent vaccination.

Area of Science:

  • Pediatric Neurology
  • Vaccinology
  • Immunology

Background:

  • Whole-cell pertussis vaccines were associated with neurological side effects.
  • Advancements led to acellular pertussis vaccines, significantly reducing these risks.

Observation:

  • A 2-month-old infant presented with recurrent generalized tonic-clonic seizures.
  • Seizures occurred following pentavalent vaccination (diphtheria, acellular pertussis, tetanus, inactivated polio, Haemophilus influenzae type B) and conjugate pneumococcal vaccine.

Findings:

  • The infant's seizures were possibly linked to the acellular pertussis component of the pentavalent vaccine.
  • This case highlights a potential, though rare, neurological adverse event associated with newer acellular pertussis vaccines.

Implications:

  • Further investigation into rare neurological adverse events following acellular pertussis vaccination is warranted.
  • This case underscores the importance of continued pharmacovigilance for all vaccine types.
  • Understanding rare side effects is crucial for maintaining public trust in vaccination programs.

Keywords:
Infantpentavalent vaccinationseizure

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