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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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TGF-β Inhibitor CILP as a Novel Biomarker for Cardiac Fibrosis

Sonja Groß1, Thomas Thum1,2

  • 1Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany, Hannover, Germany.

JACC. Basic to Translational Science
|June 2, 2020
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CILP (cartilage intermediate layer protein 1)TGF-β signalingbiomarkercardiac fibrosis

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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