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Hypoxia Induces Cardiomyocyte Proliferation in Humans

Mahmoud S Ahmed1, Hesham A Sadek1,2

  • 1Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, Texas.

JACC. Basic to Translational Science
|June 2, 2020
PubMed
Summary

No abstract available in PubMed .

Keywords:
DNA damageblood oxygen saturationcardiomyocytecardiomyocyte proliferationcongenital heart diseasehypoxia

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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