Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Designs in Epidemiology01:20

Study Designs in Epidemiology

764
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
764
Study Design in Statistics01:15

Study Design in Statistics

9.8K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
9.8K
Group Design02:01

Group Design

10.0K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
10.0K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

111
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
111
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

143
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
143
Experimental Designs01:16

Experimental Designs

16.5K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
16.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Change in the manifestations of asthma and asthma-related traits in childhood: a latent transition analysis.

The European respiratory journal·2015
Same author

Children with chronic cough: when is watchful waiting appropriate? development of likelihood ratios for assessing children with chronic cough.

Chest·2014
Same author

In reply to Badgett et al.

Academic medicine : journal of the Association of American Medical Colleges·2014
Same author

Applying established guidelines to team-based learning programs in medical schools: a systematic review.

Academic medicine :, journal of the Association of American Medical Colleges..·2014
Same author

Recruiting and retaining general practitioners to a primary care asthma-intervention study in Australia.

Australian journal of primary health·2012
Same author

A multicenter study on chronic cough in children : burden and etiologies based on a standardized management pathway.

Chest·2012

Related Experiment Video

Updated: Dec 20, 2025

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
08:33

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

7.4K

How to choose your study design.

Craig M Mellis1

  • 1Department of Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

Journal of Paediatrics and Child Health
|June 2, 2020
PubMed
Summary
This summary is machine-generated.

Choosing the right research design is crucial for accurate scientific findings. This overview explains observational and experimental study types, guiding researchers and pediatricians on selecting appropriate methods based on research questions and available resources.

Keywords:
experimental studiesobservational studiesresearch method

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

446
Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

17.0K

Related Experiment Videos

Last Updated: Dec 20, 2025

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
08:33

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

7.4K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

446
Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

17.0K

Area of Science:

  • Medical Research Methodology
  • Clinical Study Designs

Background:

  • Research designs are broadly categorized into observational studies (cross-sectional, case-control, cohort) and experimental studies (randomized controlled trials - RCTs).
  • Each study design possesses unique strengths, weaknesses, and inherent biases that influence research outcomes.
  • Understanding these designs is vital for researchers and pediatricians to ensure methodological rigor.

Purpose of the Study:

  • To provide a concise overview of common quantitative research designs.
  • To elucidate the critical factors influencing the selection of an appropriate study design.
  • To highlight the advantages and disadvantages of various research methodologies in medical research.

Main Methods:

  • This paper reviews fundamental research designs, including cross-sectional, case-control, cohort, and randomized controlled trials (RCTs).
  • It discusses the application of each design based on the specific research question (prevalence, harm, prognosis, therapy).
  • Resource availability (budget, time, feasibility, expertise) is presented as a key determinant in study design selection.

Main Results:

  • The choice of research design is primarily dictated by the research question and available resources.
  • Cross-sectional studies are suitable for prevalence, case-control for harm, cohort for prognosis, and RCTs for therapy.
  • RCTs, while ideal for therapy, are resource-intensive and may be unethical or impractical for certain research scenarios.

Conclusions:

  • Effective research requires careful consideration of study design, aligning the methodology with the research question and practical constraints.
  • Researchers and pediatricians must be aware of the pros, cons, and biases associated with each design.
  • This overview serves as an introduction, emphasizing the need for comprehensive resources for detailed study planning.