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Related Experiment Videos

[Evaluation of cascade filtration on a test sample].

F Schooneman1, F Streiff

  • 1CRTS de Nancy-Brabois, Vandoeuvre-lès-Nancy.

Annales De Medecine Interne
|January 1, 1988
PubMed
Summary

Filtration in series effectively removes plasma proteins like IgG and IgM, but faces challenges with column clogging and albumin loss. Further research aims to improve this cholesterol-removal technique.

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Area of Science:

  • Biochemistry
  • Plasma Separation
  • Filtration Technology

Context:

  • Plasma processing is crucial for therapeutic protein recovery and removal of undesirable components.
  • Filtration techniques, including double filtration and series filtration, are employed for plasma component separation.
  • Evaluating specific filtration systems like Kuraray (2A, 4A) and Dideco (Albusave) is essential for optimizing plasma treatment protocols.

Purpose:

  • To evaluate the efficacy of double filtration or filtration in series for removing specific plasma proteins (IgG, IgM, immune complexes, lipoproteins).
  • To assess the performance of Kuraray (2A, 4A) and Dideco (Albusave) filters in a biological and technical context.
  • To identify and address limitations such as column clogging and excessive albumin rejection during plasma filtration.

Summary:

  • Filtration in series demonstrates effectiveness in removing proteins like IgG, IgM, immune complexes, and lipoproteins from plasma.
  • Analysis of the sieving coefficient showed promising results, but significant challenges were identified: column slogging after filtering 2 liters and a high albumin reject coefficient.
  • Currently, no definitive solutions exist to overcome these identified filtration drawbacks.

Impact:

  • The study highlights filtration in series as a potentially valuable method for cholesterol removal from plasma.
  • Identified technical challenges necessitate further investigation and development to optimize the filtration system.
  • This research paves the way for improved plasma filtration techniques, potentially enhancing therapeutic applications and reducing treatment costs.

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