Related Experiment Video
Updated: Dec 20, 2025
Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper
Published on: February 27, 2021
Modified chicha gum by acetylation for antimicrobial and antiparasitic applications: Characterization and biological
Elton Marks Araujo Braz1, Solranny Carla Cavalcante Costa Silva2, Carla Adriana Rodrigues Sousa Brito3
1Laboratório Interdisciplinar de Materiais Avançados - LIMAV, Universidade Federal do Piauí, Campus ministro Petrônio Portela, Teresina, PI CEP 64049-550, Brazil.
Abstract:
It was developed a material to act as an antimicrobial and antiparasitic agent through a modification reaction in the gum structure extracted from the plant Sterculia striata. This material was characterized, the oxidant activity was evaluated and the antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Salmonella Typhimurium and Klebsiella pneumoniae was investigated, in addition to the effect against Leishmania amazonensis, testing its acute toxicity and its cytotoxicity in human cells. Characterization techniques proved the success of chemical modification. The modification led to an increase in antioxidant activity, with excellent antibacterial activity, reaching almost 100% inhibition for P. aeruginosa and S. Typhimurium, and inhibitory effect above 70% against L. amazonensis, with an affinity far superior to the parasite than macrophages. The derivative showed no acute toxicity, it was non-hemolytic, increased cell viability in macrophages and fibroblasts, and stimulated cell proliferation of keratinocytes, thus being a strong candidate to be used as an antimicrobial and antiparasitic agent in biomedical applications.
