Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation.

Aging cell·2026

Same author

GAK antagonises ROCK-dependent regulation of actomyosin dynamics.

Journal of cell science·2026

Same author

Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation.

bioRxiv : the preprint server for biology·2026

Same author

Microglia-to-neuron signaling links <i>APOE4</i> and inflammation to enhanced neuronal lipid metabolism and network activity.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Intravitreal NHS-Biotin Injection and Immunohistochemistry to Label and Image Protein Transport in the Mouse Optic Nerve.

Bio-protocol·2025

Same author

Editorial: Neuronal guidance signaling in health and neurological diseases.

Frontiers in cell and developmental biology·2025

Same journal

Topological skeleton analysis for network-based shape representation in biology and beyond.

iScience·2026

Same journal

Condition-specific neural signatures of reactivation during post-retrieval rest: An EEG study.

iScience·2026

Same journal

Multi-chaotic signal identification employing a causal cross-correlation neural network.

iScience·2026

Same journal

Repeated insertions at positions 261-280 in KPC-2 highlight a ceftazidime-avibactam resistance hotspot.

iScience·2026

Same journal

ROS inhibits microtubule dynamics and cell growth heterogeneity during Arabidopsis sepal morphogenesis.

iScience·2026

Same journal

Type 1 diabetes alters early macrophage-<i>Mycobacterium tuberculosis</i> transcriptional coordination during infection.

iScience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 20, 2025

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

NMDARs Translate Sequential Temporal Information into Spatial Maps.

Masaki Hiramoto¹, Hollis T Cline¹

¹The Dorris Neuroscience Center, Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

|June 2, 2020

Summary

This summary is machine-generated.

The magnitude of N-methyl-D-aspartate receptor (NMDAR) signaling influences how the brain maps sensory input timing. Reduced NMDAR responses invert spatial maps, revealing a mechanism for temporal-to-spatial information conversion.

Keywords:

Developmental Neuroscience Sensory Neuroscience Techniques in Neuroscience

More Related Videos

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

Author Spotlight: Understanding Processing of Olfactory and Spatial Information by Brain with Real-Time Behavioral Analysis

Author Spotlight: Understanding Processing of Olfactory and Spatial Information by Brain with Real-Time Behavioral Analysis

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Dec 20, 2025

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

Author Spotlight: Understanding Processing of Olfactory and Spatial Information by Brain with Real-Time Behavioral Analysis

Author Spotlight: Understanding Processing of Olfactory and Spatial Information by Brain with Real-Time Behavioral Analysis

Published on: September 20, 2024

Area of Science:

Neuroscience
Sensory processing
Synaptic plasticity

Background:

Brain circuits transform temporal sequences into spatial maps, crucial for sensory processing.
Mechanisms of this temporal-to-spatial transformation remain largely unknown.
N-methyl-D-aspartate receptor (NMDAR) response magnitude modulates synaptic plasticity.

Purpose of the Study:

Investigate if NMDAR response magnitude affects the transformation of temporal information into directional spatial maps.
Elucidate the role of NMDAR signaling in encoding temporal sequences.
Understand how temporal codes are translated into spatial representations.

Main Methods:

Quantified retinotectal axon branch dynamics in Xenopus optic tectum.
Utilized temporal sequences of visual stimulation.
Manipulated NMDAR responses to assess effects on branch dynamics.

Main Results:

Reducing NMDAR responses by 50% inverted the spatial distribution of axon branch dynamics.
This inversion occurred along the rostrocaudal axis in response to temporal input patterns.
Suggests NMDAR magnitude encodes temporal sequences.

Conclusions:

NMDAR signaling magnitude is critical for translating temporal input sequences into directional spatial maps.
Structural plasticity-based branch dynamics mediate this NMDAR-dependent decoding.
This mechanism retrieves spatial information from sequential afferent activity.