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Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report.

Ji Yun Bae¹, Ahrong Ham, Hee Jung Choi

¹Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea.

|June 3, 2020

Summary

Complement deficiencies increase susceptibility to meningococcal disease. This case report describes the first instance of C6 deficiency in Korea, highlighting the need for screening in recurrent infections.

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Area of Science:

Immunology
Infectious Diseases

Background:

Late complement deficiencies predispose individuals to meningococcal disease and recurrent infections.
While five cases of meningococcal disease with complement deficiency have been reported in Korea, C6 deficiency has not been previously documented.

Observation:

A 21-year-old police trainee experienced recurrent episodes of meningococcal meningitis.
The patient lived in communal quarters, increasing exposure risk.

Findings:

The patient was diagnosed with meningococcal meningitis attributed to C6 deficiency.
Treatment involved intravenous ceftriaxone and a post-discharge meningococcal conjugate vaccine booster.

Implications:

This case represents the first documented instance of C6 deficiency in Korea.
Routine screening for complement deficiencies is crucial for managing recurrent meningococcal infections and preventing future occurrences.