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Is Gout Associated with Pyoderma Gangrenosum? A Population-Based Case-Control Study.

Khalaf Kridin1, Ralf J Ludwig1, Dana Tzur Bitan2

  • 1Lübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.

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|June 3, 2020
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Summary

Gout significantly increases the risk of developing pyoderma gangrenosum (PG) by over fivefold. This study highlights an important association for physicians managing patients with these conditions.

Keywords:
case-control studygoutpyoderma gangrenosum

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Area of Science:

  • Dermatology
  • Rheumatology
  • Epidemiology

Background:

  • The association between pyoderma gangrenosum (PG) and gout is not well-established, despite individual case reports.
  • Understanding this potential link is crucial for clinical management and patient care.

Purpose of the Study:

  • To investigate the association between gout and pyoderma gangrenosum (PG).
  • To determine if gout predisposes individuals to the development of PG.

Main Methods:

  • A population-based case-control study design was employed.
  • 302 patients with PG were compared with 1497 matched controls regarding preceding gout diagnosis.
  • Logistic regression models were used for statistical analysis.

Main Results:

  • Preceding gout was significantly more prevalent in PG patients (3.7%) than in controls (0.7%).
  • Gout was associated with a >5-fold increased risk of PG (OR, 5.15).
  • Gout remained an independent predictor of PG after adjusting for confounders (aOR, 4.08).

Conclusions:

  • Gout is a significant risk factor for developing pyoderma gangrenosum.
  • Physicians should consider this association when treating patients with gout and PG.