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Updated: Dec 20, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
TRPV4: A Physio and Pathophysiologically Significant Ion Channel
Tamara Rosenbaum1, Miguel Benítez-Angeles1, Raúl Sánchez-Hernández1
1Departamento de Neurociencia Cognitiva, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Transient Receptor Potential channel TRPV4 (Transient Receptor Potential Vanilloid 4) is crucial in physiological processes. Its dysfunction causes severe issues, making TRPV4 a significant therapeutic target for future research and treatments.
Area of Science:
- Molecular Biology
- Physiology
- Pharmacology
Background:
- Transient Receptor Potential (TRP) channels are vital ion channels found across diverse animal species.
- The TRPV1 channel is well-studied, but TRPV4's role in various physiological and pathophysiological states is increasingly recognized.
Purpose of the Study:
- To review the significance of the TRPV4 ion channel.
- To highlight TRPV4 as a key therapeutic target.
Main Methods:
- Literature review of animal models.
- Analysis of clinical trial data.
Main Results:
- TRPV4 activity is linked to numerous physio and pathophysiological processes.
- TRPV4 dysfunction can result in severe health consequences.
Conclusions:
- TRPV4 is a critical protein with significant implications in health and disease.
- Evidence supports TRPV4 as a promising therapeutic target, warranting further investigation.
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