Related Experiment Video
Updated: Dec 20, 2025
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles
Xing Ma1, Onn Shaun Ong, Yanli Zhao
1School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798. zhaoyanli@ntu.edu.sg.
Abstract:
Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.
