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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Neoadjuvant Therapy for Melanoma.

Michael C Lowe1, Ragini R Kudchadkar2

  • 1Department of Surgery, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA.

Surgical Oncology Clinics of North America
|June 3, 2020
PubMed
Summary
This summary is machine-generated.

Neoadjuvant immunotherapy and BRAF-targeted therapies show promise for metastatic melanoma, with high response rates and good safety in smaller trials. Larger studies are ongoing to confirm benefits for resectable disease.

Keywords:
ImmunotherapyMelanomaNeoadjuvantTargeted therapy

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Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • Immune checkpoint blockade and BRAF inhibitors are standard for metastatic melanoma.
  • Growing interest exists in using these therapies before surgery (neoadjuvant setting).

Purpose of the Study:

  • To review the current landscape of neoadjuvant therapy for metastatic melanoma.
  • To assess the efficacy and safety of neoadjuvant immune checkpoint blockade and BRAF-targeted agents.

Main Methods:

  • Analysis of published clinical trials evaluating neoadjuvant therapies for melanoma.
  • Review of pathologic response rates and safety data from these trials.

Main Results:

  • Numerous smaller clinical trials have reported promising results.
  • High pathologic response rates and acceptable safety profiles have been observed.

Conclusions:

  • Neoadjuvant therapy with immune checkpoint blockade and BRAF inhibitors demonstrates potential in resectable metastatic melanoma.
  • Larger randomized trials are necessary to establish the role of neoadjuvant therapy in standard care.