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MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis

Jiyoung Kim1, Hyeryun Kwon1, You Keun Shin2

  • 1Department of Life Science, University of Seoul, 02504 Seoul, Republic of Korea.

Proceedings of the National Academy of Sciences of the United States of America
|June 3, 2020
PubMed
Summary

Mastermind-like 1 and 2 (MAML1/2) are crucial for YAP/TAZ nuclear localization and function. This axis, regulated by microRNA-30c, is implicated in cancer development and may offer new therapeutic targets.

Keywords:
Hippo signalingMAML1/2TEADYAP/TAZnuclear localization

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