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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Updated: Dec 20, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

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Aerosolized Chemotherapy for Osteosarcoma.

Nancy Gordon1, Kumar Felix2, Najat C Daw3

  • 1Department of Pediatrics Research, MD Anderson Cancer Center, Houston, TX, USA. ngordon@mdanderson.org.

Advances in Experimental Medicine and Biology
|June 3, 2020
PubMed
Summary
This summary is machine-generated.

Inhalation chemotherapy effectively treats lung cancer by delivering drugs directly to the lungs, reducing side effects. Aerosolized gemcitabine shows promise in regressing osteosarcoma lung metastases and improving survival.

Keywords:
AerosolGemcitabineInhalation therapyLung metastasesOsteosarcoma

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Area of Science:

  • Oncology
  • Pulmonary Medicine
  • Pharmacology

Background:

  • Inhalation therapy offers a targeted approach for lung diseases, including cancer, with fewer systemic side effects compared to traditional chemotherapy.
  • Direct delivery to the lungs overcomes limitations of systemic chemotherapy, enabling higher drug concentrations and sparing vital organs.

Purpose of the Study:

  • To evaluate the efficacy of aerosol chemotherapy in treating pulmonary metastases of osteosarcoma (OS).
  • To highlight the use of gemcitabine as an inhaled chemotherapeutic agent for lung diseases.
  • To describe an ongoing study on aerosolized gemcitabine for solid tumors with lung metastases and home-based lung health monitoring.

Main Methods:

  • Utilized various osteosarcoma mouse models to assess the impact of aerosol chemotherapy.
  • Administered gemcitabine, a nucleoside analog, via inhalation.
  • Reviewed existing data on inhaled chemotherapeutic agents and presented an ongoing clinical study.

Main Results:

  • Aerosol chemotherapy demonstrated regression of pulmonary metastases and improved survival in mice with osteosarcoma.
  • Phase I study indicated aerosol gemcitabine is feasible and safe for primary lung cancer patients.
  • Ongoing research focuses on aerosolized gemcitabine for solid tumors with lung metastases.

Conclusions:

  • Inhalation chemotherapy, particularly with gemcitabine, is a viable and effective strategy for managing lung metastases.
  • This approach offers a promising alternative with reduced toxicity for patients with lung cancer and metastatic disease.
  • Future directions include home-based lung health monitoring to support widespread adoption of this therapy.